Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | CNR2 | P34972 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27728387 | 0.89 | POLB (0.72) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL28339249 | 0.87 | L3MBTL1 (0.64) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL28924432 | 0.86 | MAPT (0.52) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL27728374 | 0.86 | CHRM1 (0.67) | L3MBTL1NPSR1HTTMAPK1LMNA | |
| SCHEMBL27707840 | 0.86 | L3MBTL1 (0.55) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL5852445 | 0.84 | NPSR1 (0.81) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL1606606 | 0.84 | LMNA (0.80) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL3865315 | 0.83 | L3MBTL1 (0.71) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL28774047 | 0.83 | PARP1 (0.52) | L3MBTL1ADORA1NPSR1HTTCYP1A2 | |
| SCHEMBL27707835 | 0.83 | MAPT (0.65) | L3MBTL1NPSR1HTTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108033969-B | Oxoindolspirotetrahydrofuran compound and preparation method and application thereof | 中国医药集团总公司四川抗菌素工业研究所 | 2020-04-10 | — | — | CN | disclosed |
| CN-108033969-A | A kind of Oxoindole spiral shell tetrahydrofuran-compound and its preparation method and application | 中国医药集团总公司四川抗菌素工业研究所 | 2018-05-15 | — | — | CN | disclosed |
| CN-101213174-A | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC (CA) | 2008-07-02 | — | — | CN | disclosed |