Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.66 |
| ▸ | EIF4E | P06730 | 6/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28859698 | 0.88 | MKNK1 (0.66) | MKNK1MKNK2EIF4ENPC1RAB9A | |
| SCHEMBL28217090 | 0.84 | ALDH1A1 (0.52) | MKNK1MKNK2EIF4EALDH1A1TNKS | |
| SCHEMBL2933369 | 0.81 | ATR (0.67) | MKNK1MKNK2EIF4EHPGD | |
| SCHEMBL28217093 | 0.81 | ALDH1A1 (0.51) | MKNK1MKNK2EIF4ENPC1RAB9A | |
| SCHEMBL22697152 | 0.80 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL18889298 | 0.78 | MAPT (0.78) | NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL8150805 | 0.77 | HPGD (0.76) | NPC1RAB9AALDH1A1HPGDTSHR | |
| SCHEMBL980203 | 0.76 | TNKS (0.66) | NPC1RAB9AALDH1A1TNKSTSHR | |
| SCHEMBL10720943 | 0.75 | PHGDH (0.81) | ALDH1A1HPGDTSHR | |
| SCHEMBL16385826 | 0.75 | HPGD (0.54) | MKNK1MKNK2EIF4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |