Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 10/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TNKS | O95271 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | EIF4E | P06730 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28216628 | 0.88 | MKNK1 (0.66) | MKNK1MKNK2HPGDALDH1A1TNKS | |
| SCHEMBL28217090 | 0.85 | ALDH1A1 (0.52) | MKNK1MKNK2ALDH1A1TNKSEIF4E | |
| SCHEMBL28217093 | 0.82 | ALDH1A1 (0.51) | MKNK1MKNK2ALDH1A1TNKSNPC1 | |
| SCHEMBL22697276 | 0.80 | MKNK1 (1.00) | MKNK1MKNK2EIF4E | |
| SCHEMBL16385826 | 0.78 | HPGD (0.54) | MKNK1MKNK2HPGDALDH1A1TNKS | |
| SCHEMBL22697335 | 0.78 | MKNK1 (0.98) | MKNK1MKNK2EIF4E | |
| SCHEMBL19864572 | 0.77 | ALDH1A1 (1.00) | HPGDALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL15170873 | 0.77 | ALDH1A1 (1.00) | HPGDALDH1A1L3MBTL1POLBMAPT | |
| SCHEMBL980203 | 0.77 | TNKS (0.66) | ALDH1A1MAPK1TNKSNPC1TSHR | |
| SCHEMBL11851303 | 0.77 | NPC1 (0.56) | MKNK1MKNK2HPGDNPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |