Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518360 | 0.83 | SNCA (0.36) | — | |
| SCHEMBL32670704 | 0.82 | SNCA (0.30) | — | |
| SCHEMBL16426110 | 0.82 | ALOX15 (0.37) | — | |
| SCHEMBL16974592 | 0.81 | ALDH1A1 (0.39) | CA1CA2PDE3ALPLLIPG | |
| SCHEMBL16426136 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL16974558 | 0.80 | ALDH1A1 (0.38) | CA1CA2PDE3ALPLLIPG | |
| SCHEMBL1095116 | 0.79 | LPL (0.47) | CA1CA2PDE3ACA3CA6 | |
| SCHEMBL19171259 | 0.78 | CA1 (0.38) | CA1CA2PDE3ALPLLIPG | |
| SCHEMBL3220980 | 0.77 | HPGD (0.33) | CA1CA2CA3CA5ACA9 | |
| SCHEMBL615942 | 0.77 | ALDH1A1 (0.38) | CA1CA2PDE3ALPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069504-A1 | (3-OXO)PYRIDIN-4-YLUREA DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL, S.A. (ES) | 2010-06-24 | — | — | WO | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |