SCHEMBL28217646

SCHEMBL28217646

Cc1cccc(C)c1C=O.O=Cc1cc(F)ccc1F

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 5/20 0.44
ALDH1A1 P00352 2/20 0.41
TSHR P16473 1/20 0.41
ERN1 O75460 3/20 0.41
KDM4E B2RXH2 1/20 0.37
CXCR5 P32302 2/20 0.37
S1PR2 O95136 1/20 0.36
S1PR4 O95977 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL65723 0.82 ERN1 (0.56) NFE2L2ALDH1A1ERN1KDM4E
SCHEMBL66979 0.75 ALDH1A1 (0.52) NFE2L2ALDH1A1TSHRKDM4E
Methylene Chloride SCHEMBL28191198 0.74 ERN1 (0.48) NFE2L2ALDH1A1ERN1KDM4E
SCHEMBL29432845 0.74 ALDH1A1 (0.48) NFE2L2ALDH1A1TSHRERN1KDM4E
SCHEMBL1663012 0.74 ACHE (0.48) NFE2L2ALDH1A1TSHRERN1
SCHEMBL41736 0.74 ALDH1A1 (0.48) NFE2L2ALDH1A1TSHRERN1KDM4E
SCHEMBL31227003 0.74 ACHE (0.48) NFE2L2ALDH1A1TSHRERN1
SCHEMBL28641344 0.73 ALDH1A1 (0.50) NFE2L2ALDH1A1TSHRKDM4E
SCHEMBL7553407 0.72 NFE2L2 (0.46) NFE2L2ALDH1A1ERN1
SCHEMBL548632 0.72 ALDH1A1 (0.62) ALDH1A1TSHRERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105503731-B 1- (2,6- dichlor-4-trifluoromethyls) phenyl -3- cyano group -5- methylenes amino-pyrazol type compound and its micro-wave digestion synthetic method and application 中南民族大学 2018-05-15 CN disclosed