Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10900007 | 0.80 | KDM4E (0.48) | HDAC4HDAC2HDAC8HDAC6PTPRC | |
| SCHEMBL28218475 | 0.74 | KDM4E (0.50) | PTPRCKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23925707 | 0.73 | HDAC4 (0.53) | HDAC4HDAC2HDAC8HDAC6PTPRC | |
| SCHEMBL25706171 | 0.71 | CHRM2 (0.51) | PTPRCALDH1A1HPGDHSD17B10CHRM2 | |
| SCHEMBL28218017 | 0.70 | KDM4E (0.38) | PTPRCKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL28218014 | 0.70 | KDM4E (0.38) | PTPRCKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL887941 | 0.69 | CHRM2 (0.50) | PTPRCKDM4EALDH1A1MEN1CYP3A4 | |
| SCHEMBL31412182 | 0.68 | BACE1 (0.48) | HDAC4HDAC2HDAC8HDAC6KDM4E | |
| SCHEMBL21471576 | 0.68 | HDAC4 (1.00) | HDAC4HDAC2HDAC8HDAC6ALDH1A1 | |
| SCHEMBL12270202 | 0.66 | CHRM2 (0.47) | PTPRCKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524034-B | Preparation, pharmacological action and the application for treating cerebral ischemia of coumarin derivative | 北京大学 | 2018-08-17 | — | — | CN | disclosed |
| CN-105566269-B | Preparation, pharmacological action and the application for treating itch of coumarin derivative | 北京大学 | 2018-07-10 | — | — | CN | disclosed |