SCHEMBL282227

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL10127132	0.89	SYK (0.38)	ZAP70HSD17B10SYKMEN1KMT2A
	SCHEMBL17689748	0.89	ZAP70 (0.41)	ZAP70HSD17B10SYKKDM4EMAPT
	SCHEMBL283672	0.89	EGFR (0.45)	ZAP70MEN1KMT2AKDM4EMAPT
	SCHEMBL283679	0.84	CA1 (0.45)	SYKMEN1KMT2AMAPTPOLB
	SCHEMBL13070939	0.78	TNF (0.39)	ZAP70SYKMAPTLMNAMAPK8
	SCHEMBL13071122	0.77	NTRK1 (0.47)	ZAP70MEN1KMT2AKDM4EMAPT
	SCHEMBL10127077	0.77	ZAP70 (0.38)	ZAP70HSD17B10SYKPOLBGAA
	SCHEMBL10157923	0.75	KIT (0.38)	ZAP70SYKMAPK8FLT4
	SCHEMBL328299	0.74	PDE4B (0.41)	ZAP70SYKMEN1KMT2AKDM4E
	SCHEMBL10127075	0.74	XDH (0.42)	ZAP70SYKMEN1KMT2ABTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.