Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29222403 | 0.88 | LCK (0.48) | CYP3A4USP2MAPK1SMN1; SMN2LCK | |
| SCHEMBL466144 | 0.88 | CYP3A4 (0.60) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 | |
| SCHEMBL28390127 | 0.83 | CYP3A4 (0.51) | CYP3A4USP2MAPK1SMN1; SMN2LCK | |
| SCHEMBL5183726 | 0.81 | ALDH1A1 (0.50) | LCKFYNCA12CA1CA2 | |
| SCHEMBL15532566 | 0.81 | HPGD (0.60) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 | |
| SCHEMBL6507929 | 0.81 | SMN1; SMN2 (0.53) | CYP3A4USP2MAPK1SMN1; SMN2LCK | |
| SCHEMBL1614609 | 0.81 | CYP3A4 (0.73) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 | |
| SCHEMBL21932914 | 0.81 | KMT2A (0.57) | CYP3A4MAPK1LCKFYNCA1 | |
| SCHEMBL311761 | 0.81 | KMT2A (0.57) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 | |
| SCHEMBL28320490 | 0.80 | CYP3A4 (0.49) | CYP3A4USP2MAPK1SMN1; SMN2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116493-B | Method for preparing Apabetalone, intermediate and preparation method of intermediate | 上海工程技术大学 | 2021-07-27 | — | — | CN | claimed |
| CN-111116493-A | Method for preparing Apabetalone, intermediate and preparation method of intermediate | 上海工程技术大学 | 2020-05-08 | — | — | CN | claimed |
| CN-108218798-B | Preparation method of Apabetalone | 南方医科大学 | 2020-04-24 | — | — | CN | claimed |
| CN-115710202-B | Preparation method and application of apataone key intermediate | 江西同和药业股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115710202-A | Preparation method and application of apatazone key intermediate | 江西同和药业股份有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-111116493-B | Method for preparing Apabetalone, intermediate and preparation method of intermediate | 上海工程技术大学 | 2021-07-27 | — | — | CN | disclosed |
| CN-111116493-B | Method for preparing Apabetalone, intermediate and preparation method of intermediate | 上海工程技术大学 | 2021-07-27 | — | — | CN | disclosed |
| CN-108997226-B | Synthesis process of cardiovascular drug Apabetalone | 合肥学院 | 2020-10-02 | — | — | CN | disclosed |
| CN-111116493-A | Method for preparing Apabetalone, intermediate and preparation method of intermediate | 上海工程技术大学 | 2020-05-08 | — | — | CN | disclosed |
| CN-111116493-A | Method for preparing Apabetalone, intermediate and preparation method of intermediate | 上海工程技术大学 | 2020-05-08 | — | — | CN | disclosed |
| CN-108218798-B | Preparation method of Apabetalone | 南方医科大学 | 2020-04-24 | — | — | CN | disclosed |
| CN-108218798-A | The preparation method of Apabetalone | 南方医科大学 | 2018-06-29 | — | — | CN | disclosed |