Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15440287 | 0.88 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL466144 | 0.88 | CYP3A4 (0.60) | SMN1; SMN2USP2CYP3A4MAPK1KDM4E | |
| SCHEMBL12135841 | 0.87 | GAA (0.51) | SMN1; SMN2USP2CYP3A4MAPK1KDM4E | |
| SCHEMBL4844145 | 0.84 | CYP3A4 (0.46) | SMN1; SMN2USP2CYP3A4MAPK1KDM4E | |
| SCHEMBL4841792 | 0.83 | NPC1 (0.62) | SMN1; SMN2CYP3A4MAPK1ALDH1A1HPGD | |
| SCHEMBL9806970 | 0.82 | HTT (0.52) | SMN1; SMN2USP2CYP3A4MAPK1ALDH1A1 | |
| SCHEMBL1651653 | 0.81 | KDM4E (0.49) | SMN1; SMN2USP2CYP3A4MAPK1KDM4E | |
| SCHEMBL4847814 | 0.81 | KDM4E (0.53) | SMN1; SMN2KDM4EALDH1A1HPGDLCK | |
| SCHEMBL31208074 | 0.81 | CA12 (0.55) | SMN1; SMN2USP2CYP3A4MAPK1KDM4E | |
| SCHEMBL4959972 | 0.81 | CA12 (0.55) | SMN1; SMN2USP2CYP3A4MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103086947-A | Phthalimide compounds with antiangiogenic activity and purpose thereof | ZHAO QINGCHUN | 2013-05-08 | — | — | CN | disclosed |
| US-20050043411-A1 | Process for preparing homophthalate derivatives | TJGEL, LLC | 2005-02-24 | — | — | US | disclosed |
| US-6797838-B2 | Process for preparing homophthalate derivatives | ILEX PRODUCTS, INC. | 2004-09-28 | — | — | US | disclosed |
| EP-1404662-A2 | PROCESS FOR PREPARING ISOCOUMARINS | Ilex Products, Inc. (US) | 2004-04-07 | — | — | EP | disclosed |
| US-20040024240-A1 | Process for preparing homophthalate derivatives | GENZYME CORPORATION | 2004-02-05 | — | — | US | disclosed |
| US-6664401-B2 | Reacting a isochroman-1,3-dione with a carbonyl compound whose carbonyl group is substituted with an acyl activating group, in the presence of a base and a solvent; use making anticancer agents for example | ILEX PRODUCTS, INC. | 2003-12-16 | — | — | US | disclosed |
| US-20030105340-A1 | Process for preparing isocoumarins | GENZYME CORPORATION | 2003-06-05 | — | — | US | disclosed |
| WO-2003004486-A2 | PROCESS FOR PREPARING ISOCOUMARINS | ILEX PRODUCTS, INC. (US) | 2003-01-16 | — | — | WO | disclosed |
| US-4755579-A | Autoaccelerated organopolysiloxane elastomers | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1988-07-05 | — | — | US | disclosed |
| US-4584256-A | AGING RESISTANCE | RHONE-POULENC SYSTEMES (FR) | 1986-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105340-A1 | Process for preparing isocoumarins | DHPS, IDH2, IDH1 | SMN1; SMN2 4741/4885USP2 2444/4885CYP3A4 32/4885 |
| US-20050043411-A1 | Process for preparing homophthalate derivatives | HPD, HAAO, PAH | SMN1; SMN2 4831/4885USP2 664/4885CYP3A4 9/4885 |
| US-20040024240-A1 | Process for preparing homophthalate derivatives | HPD, HAAO, PAH | SMN1; SMN2 4831/4885USP2 664/4885CYP3A4 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.