Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL31158052 | 0.89 | MAPT (0.41) | CYP1A2CYP2D6MAPTRAB9ALMNA | |
| Chlorobenzene SCHEMBL28131093 | 0.86 | TSHR (0.50) | CYP1A2RAB9ATSHRKMT2AMEN1 | |
| Maleic Acid SCHEMBL27497623 | 0.80 | TSHR (0.58) | CYP1B1CYP2D6MAOBMAPTRAB9A | |
| Maleic Acid SCHEMBL27502549 | 0.78 | TSHR (0.55) | CYP1B1CYP2D6MAOBMAPTRAB9A | |
| Maleic Acid SCHEMBL27579369 | 0.78 | TSHR (0.55) | CYP1B1CYP2D6MAOBMAPTRAB9A | |
| Maleic Acid SCHEMBL27751325 | 0.78 | TSHR (0.55) | CYP1B1CYP2D6MAOBMAPTRAB9A | |
| Maleic Acid SCHEMBL27640241 | 0.75 | HCAR2 (0.44) | CYP1B1CYP2D6MAOBMAPTRAB9A | |
| Cadaverine Tartrate SCHEMBL28783254 | 0.73 | TSHR (0.40) | MAPTLMNATSHRKMT2AHSD17B10 | |
| Benzene SCHEMBL28086885 | 0.73 | AURKA (0.46) | MAPTTSHRSMN1; SMN2HDAC8HDAC6 | |
| Sulfuric Acid SCHEMBL28053839 | 0.72 | AURKA (0.43) | CYP1A2MAPTRAB9ATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103327964-B | It forms the method for miniemulsion and the miniemulsion is used to deliver the purposes of biological action agent | NS技术私人有限公司 | 2018-06-29 | — | — | CN | disclosed |