Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.34 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL27801477 | 0.91 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1MGAMGAA | |
| Styrene SCHEMBL27941064 | 0.91 | ALDH1A1 (0.58) | ALDH1A1TSHRTDP1MGAMGAA | |
| Styrene SCHEMBL1261405 | 0.83 | ALDH1A1 (0.70) | ALDH1A1TSHRTDP1KMT2AMAPT | |
| Styrene SCHEMBL5604788 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1KMT2AMAPT | |
| Styrene SCHEMBL9625915 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1KMT2AMAPT | |
| Styrene SCHEMBL15313173 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1KMT2AMAPT | |
| Styrene SCHEMBL4274360 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1KMT2AMAPT | |
| Styrene SCHEMBL11292367 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1MGAMGAA | |
| Styrene SCHEMBL904376 | 0.81 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1MGAMGAA | |
| Styrene SCHEMBL2981589 | 0.81 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1MAOBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108166273-A | It is a kind of for dispersion dye leveller of polyester fiber and preparation method thereof | 苏州维明化学工业有限公司 | 2018-06-15 | — | — | CN | disclosed |