Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9452527 | 0.79 | — | — | |
| SCHEMBL8846435 | 0.76 | TSHR (0.32) | TSHR | |
| SCHEMBL4160188 | 0.74 | ACACB (0.38) | TSHR | |
| SCHEMBL28523280 | 0.71 | TSHR (0.36) | TSHR | |
| SCHEMBL10525100 | 0.71 | ALDH1A1 (0.37) | TSHR | |
| Silver SCHEMBL9709907 | 0.70 | CA2 (0.35) | TSHR | |
| SCHEMBL9710130 | 0.70 | CA2 (0.38) | TSHR | |
| SCHEMBL506180 | 0.69 | TSHR (0.38) | TSHR | |
| SCHEMBL100145 | 0.65 | — | — | |
| SCHEMBL3277841 | 0.65 | ALDH1A1 (0.32) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050749-B1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2017-11-22 | — | — | EP | disclosed |
| EP-2483340-B1 | UV-STABLE POLYCARBONATE COMPOSITIONS WITH IMPROVED PROPERTIES | BAYER IP GMBH (DE) | 2014-12-17 | — | — | EP | disclosed |
| US-20100324284-A1 | PYRROLOPYRIMIDINE DERIVATIVE AS P13K INHIBITOR AND USE THEREOF | CHUGAI SEIYAKU KABUSHIKI KAISHA | 2010-12-23 | — | — | US | disclosed |
| EP-2239261-A1 | PYRROLOPYRIMIDIN DERIVATIVE FOR USE AS PI3K INHIBITOR, AND USE THEREOF | Chugai Seiyaku Kabushiki Kaisha (JP) | 2010-10-13 | — | — | EP | disclosed |
| US-20100069629-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITOR AND USE THEREOF | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-03-18 | — | — | US | disclosed |
| EP-2050749-A1 | PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2009-04-22 | — | — | EP | disclosed |
| EP-1311471-B1 | PHENYL- AND PHENYLALKYL-SUBSTITUTED ETHANOLAMINES AND ETHYLENEDIAMINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-04-12 | — | — | EP | disclosed |
| US-20040162428-A1 | 6-(2,6-difluorophenyl)-triazolopyrimidines as fungicides | BASF AKTIENGESELLSCHAFT (DE) | 2004-08-19 | — | — | US | disclosed |
| US-6444748-B1 | ADJUSTMENT OF PH; MULTISTAGE POLYMERIZATION | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162428-A1 | 6-(2,6-difluorophenyl)-triazolopyrimidines as fungicides | CBR3, CBR1, CNPY2 | TSHR 2408/4885 |
| US-20100069629-A1 | PYRIMIDINE DERIVATIVES AS PI3K INHIBITOR AND USE THEREOF | PIK3CA, AKT3, AKT1 | TSHR 3412/4885 |
| US-20100324284-A1 | PYRROLOPYRIMIDINE DERIVATIVE AS P13K INHIBITOR AND USE THEREOF | CSNK1A1, CSK, CSNK1A1L | TSHR 3447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.