Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9710130 | 0.95 | CA2 (0.38) | CA2CYP3A4TSHRNFKB1NPSR1 | |
| SCHEMBL4160188 | 0.76 | ACACB (0.38) | CA2TSHR | |
| Silver SCHEMBL17797183 | 0.76 | CA2 (0.39) | CA2 | |
| SCHEMBL9709917 | 0.74 | ACACB (0.36) | CA2TSHR | |
| Dimebutic Acid SCHEMBL13517329 | 0.72 | — | — | |
| SCHEMBL15022216 | 0.71 | CA2 (0.39) | CA2 | |
| SCHEMBL2822855 | 0.70 | TSHR (0.33) | TSHR | |
| Silver SCHEMBL17797177 | 0.69 | FFAR3 (0.38) | CA2CYP3A4TSHRNFKB1NPSR1 | |
| Dimebutic Acid SCHEMBL15022227 | 0.67 | — | — | |
| Silver SCHEMBL978772 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5117022-A | Antitumor | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1992-05-26 | — | — | US | disclosed |
| WO-1990002131-A1 | HYDROPHOBIC CIS-PLATINUM COMPLEXES EFFICIENTLY INCORPORATED INTO LIPOSOMES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1990-03-08 | — | — | WO | disclosed |