Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PPID | Q08752 | 2/20 | 0.45 |
| ▸ | PPIB | P23284 | 1/20 | 0.45 |
| ▸ | PPIA | P62937 | 1/20 | 0.45 |
| ▸ | PPIG | Q13427 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3309951 | 0.83 | GAA (0.57) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL13809612 | 0.81 | GAA (0.55) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL27707684 | 0.81 | GAA (0.55) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL27687085 | 0.80 | — | — | |
| SCHEMBL10470968 | 0.80 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL4104132 | 0.79 | GAA (0.53) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15290166 | 0.79 | GAA (0.53) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL5184954 | 0.78 | GAA (0.68) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL7089973 | 0.78 | GAA (0.61) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL7946756 | 0.78 | PPID (0.62) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020107221-A1 | CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF | TSINGHUA UNIVERSITY (CN) | 2020-06-04 | — | — | WO | disclosed |
| US-RE41289-E1 | Ultrashort acting hypnotic barbiturates | ARYX THERAPEUTICS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-RE41289-E1 | Ultrashort acting hypnotic barbiturates | ARYX THERAPEUTICS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-RE41289-E1 | Ultrashort acting hypnotic barbiturates | ARYX THERAPEUTICS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-7041673-B2 | High speed metabolism; antiepileptic agents; anesthetics; central nervous system disorders; anxiolytic agents | ARYX THERAPEUTICS, INC. (US) | 2006-05-09 | — | — | US | disclosed |
| US-20040167143-A1 | Ultrashort acting hypnotic barbiturates | MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC | 2004-08-26 | — | — | US | disclosed |
| US-6683086-B2 | DERIVATIVES OF BARBITURIC AND THIOBARBITURIC ACIDS; RAPIDLY METABOLIZED BY BLOOD AND TISSUE ENZYMES TO FORM POLAR METABOLITES WITH NO HYPNOTIC ACTIVITY AND WHICH ARE RAPIDLY ELIMINATED | ARYX THERAPEUTICS | 2004-01-27 | — | — | US | disclosed |
| US-20030100575-A1 | Ultrashort acting hypnotic barbiturates | MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC | 2003-05-29 | — | — | US | disclosed |
| EP-1276728-A2 | ULTRASHORT ACTING HYPNOTIC BARBITURATES | ARYx Therapeutics (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6387914-B2 | PROVIDING SEDATIVE-HYPNOTIC TREATMENT BY ADMINISTERING BARBITURATE DERIVATIVE COMPOUND | ARYX THERAPEUTICS | 2002-05-14 | — | — | US | disclosed |
| US-20020013330-A1 | Ultrashort acting hypnotic barbiturates | MPM ASSET MANAGEMENT INVESTORS 2002 BVIII LLC | 2002-01-31 | — | — | US | disclosed |
| WO-2001081319-A2 | ULTRASHORT ACTING HYPNOTIC BARBITURATES | ARYX THERAPEUTICS (US) | 2001-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167143-A1 | Ultrashort acting hypnotic barbiturates | GABRR1, GABRA1, GABRR2 | GAA 1247/4885MGAM 1424/4885SI 815/4885 |
| US-20030100575-A1 | Ultrashort acting hypnotic barbiturates | GABRR1, GABRA1, GABRR2 | GAA 1247/4885MGAM 1424/4885SI 815/4885 |
| US-20020013330-A1 | Ultrashort acting hypnotic barbiturates | GABRR1, GABRA1, GABRR2 | GAA 1247/4885MGAM 1424/4885SI 815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.