Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 15/20 | 0.46 |
| ▸ | KDM6B | O15054 | 7/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KDM4A | O75164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29952392 | 0.87 | KDM4C (0.53) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL2848389 | 0.87 | KDM4C (0.53) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL3284891 | 0.76 | TDP1 (0.50) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL29955774 | 0.74 | KDM4C (0.48) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL4619119 | 0.74 | KDM4C (0.48) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL10639037 | 0.73 | HIPK2 (0.40) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL13320901 | 0.73 | MAPT (0.44) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL116060 | 0.72 | KDM4C (0.55) | KDM4CKDM6BKDM4DKDM4EKDM4A | |
| SCHEMBL29467363 | 0.72 | ALDH1A1 (0.58) | KDM4CKDM4EALDH1A1KMT2ATDP1 | |
| SCHEMBL2847922 | 0.72 | ALDH1A1 (0.58) | KDM4CKDM4EALDH1A1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108250183-A | A kind of preparation method of the Topiroxostat of high-purity | 北京诚济制药有限公司 | 2018-07-06 | — | — | CN | disclosed |