Sugi Predict

Sugi Predict / Compounds / SCHEMBL4619119

SCHEMBL4619119

SCHEMBL4619119

N#Cc1ccncc1C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KDM4C Q9H3R0 6/20 0.48
▸ KMT2A Q03164 3/20 0.48
▸ KDM6B O15054 3/20 0.48
▸ KDM4D Q6B0I6 3/20 0.48
▸ MEN1 O00255 2/20 0.48
▸ TDP1 Q9NUW8 2/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ KDM4A O75164 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ MAPT P10636 1/20 0.48
▸ THRB P10828 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ SLC22A12 Q96S37 4/20 0.46
▸ HTT P42858 1/20 0.41
▸ ELANE P08246 2/20 0.40
▸ XDH P47989 1/20 0.40
▸ SIRT3 Q9NTG7 1/20 0.39
▸ NAPRT Q6XQN6 1/20 0.39
▸ HIPK2 Q9H2X6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29955774 1.00 KDM4C (0.48) KDM4CKMT2AKDM6BKDM4DMEN1
SCHEMBL29952392 0.85 KDM4C (0.53) KDM4CKMT2AKDM6BKDM4DMEN1
SCHEMBL2848389 0.85 KDM4C (0.53) KDM4CKMT2AKDM6BKDM4DMEN1
SCHEMBL30874483 0.83 SIRT3 (0.55) KDM4CKMT2AKDM6BKDM4DMEN1
SCHEMBL17260712 0.83 MAPT (0.44) KMT2AMEN1TDP1KDM4EALDH1A1
SCHEMBL10526335 0.82 KDM4C (0.50) KDM4CKMT2AKDM6BKDM4DMEN1
SCHEMBL8182630 0.81 KDM4C (0.48) KDM4CKMT2AKDM6BKDM4DMEN1
SCHEMBL25085773 0.79 ALDH1A1 (0.54) KMT2ATDP1KDM4EALDH1A1L3MBTL1
SCHEMBL31114552 0.75 KDM4E (0.46) KDM4CKMT2AKDM6BKDM4DMEN1
SCHEMBL29416303 0.74 KDM4C (0.65) KDM4CKMT2AKDM6BKDM4DMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119381690-B Cellulose-based lithium ion battery diaphragm capable of promoting lithium ion migration and preparation method and application thereof 华南理工大学 2025-04-22 — — CN disclosed
US-20250092040-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2025-03-20 — — US disclosed
CN-119381690-A Cellulose-based lithium ion battery diaphragm capable of promoting lithium ion migration and preparation method and application thereof 华南理工大学 2025-01-28 — — CN disclosed
US-20240239797-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2024-07-18 — — US disclosed
US-11999730-B1 AKT1 modulators ALTEROME THERAPEUTICS, INC. (US) 2024-06-04 — — US disclosed
US-20240174667-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. 2024-05-30 — — US disclosed
EP-4143195-A1 IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 Janssen Pharmaceutica NV (BE) 2023-03-08 — — EP disclosed
EP-3204383-B1 SPIRODIAMINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS HOFFMANN LA ROCHE (CH) 2020-11-18 — — EP disclosed
US-10035804-B2 Spirodiamine derivatives as aldosterone synthase inhibitors HOFFMAN-LA ROCHE INC. (US) 2018-07-31 — — US disclosed
US-20170204107-A1 SPIRODIAMINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2017-07-20 — — US disclosed
US-8299055-B2 8-substituted isoquinoline derivative and the use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2012-10-30 — — US disclosed
US-8299055-B2 8-substituted isoquinoline derivative and the use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2012-10-30 — — US disclosed
US-20100261701-A1 8-Substituted isoquinoline derivative and the use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2010-10-14 — — US disclosed
US-20100261701-A1 8-Substituted isoquinoline derivative and the use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2010-10-14 — — US disclosed
WO-2010038465-A1 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF 旭化成ファーマ株式会社 (JP) 2010-04-08 — — WO disclosed
EP-1885697-A2 SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-02-13 — — EP disclosed
US-20060276515-A1 Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-12-07 — — US disclosed
WO-2006121719-A2 SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) 2006-11-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239797-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 KDM4C 3552/4885KMT2A 1301/4885KDM6B 2248/4885
US-20170204107-A1 SPIRODIAMINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS REN, NR3C2, CYP21A2 KDM4C 3863/4885KMT2A 3669/4885KDM6B 3822/4885
US-10035804-B2 Spirodiamine derivatives as aldosterone synthase inhibitors REN, NR3C2, CYP21A2 KDM4C 3863/4885KMT2A 3669/4885KDM6B 3822/4885
US-20100261701-A1 8-Substituted isoquinoline derivative and the use thereof RELA, NFKBIA, NFKB2 KDM4C 2269/4885KMT2A 637/4885KDM6B 2376/4885
US-20060276515-A1 Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same EPHX1, EPHX2, NCEH1 KDM4C 1629/4885KMT2A 3145/4885KDM6B 889/4885
US-20250092040-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 KDM4C 3552/4885KMT2A 1301/4885KDM6B 2248/4885
US-11999730-B1 AKT1 modulators AKT1S1, AKT1, AKT2 KDM4C 3552/4885KMT2A 1301/4885KDM6B 2248/4885
US-20240174667-A1 AKT1 MODULATORS AKT1S1, AKT1, AKT2 KDM4C 3552/4885KMT2A 1301/4885KDM6B 2248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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