Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316406 | 0.85 | SMN1; SMN2 (0.55) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL28229641 | 0.83 | FFAR1 (0.51) | MMP12HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL27802263 | 0.82 | LMNA (0.56) | MMP12HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL29197998 | 0.79 | MAPT (0.55) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5907106 | 0.77 | MEN1 (0.41) | MMP12FFAR1MEN1KMT2A | |
| SCHEMBL1448093 | 0.77 | KEAP1 (0.52) | ACLYFFAR1 | |
| SCHEMBL7239123 | 0.76 | HDAC1 (0.70) | MMP12HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL28229640 | 0.75 | FFAR1 (0.42) | MMP12HDAC1HDAC7FFAR1 | |
| SCHEMBL34471011 | 0.74 | HDAC3 (0.47) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL27816726 | 0.74 | HDAC1 (0.47) | MMP12HDAC1HDAC8FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036014-A | A kind of compound and its preparation and application with AXL inhibitory activity | 中国科学院上海药物研究所 | 2019-07-19 | — | — | CN | disclosed |
| CN-108250200-A | A kind of compound and its preparation and application with Axl inhibitory activity | 中国科学院上海药物研究所 | 2018-07-06 | — | — | CN | disclosed |