Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 4/20 | 0.50 |
| ▸ | MMP8 | P22894 | 2/20 | 0.50 |
| ▸ | MMP12 | P39900 | 2/20 | 0.50 |
| ▸ | MMP13 | P45452 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5273134 | 1.00 | KMT2A (0.57) | KMT2APIN1ITGB3ITGA2BMMP2 | |
| SCHEMBL402067 | 0.92 | SMN1; SMN2 (0.55) | KMT2APIN1ITGB3ITGA2BMMP2 | |
| SCHEMBL29734985 | 0.91 | MMP2 (0.59) | KMT2APIN1ITGB3ITGA2BMMP2 | |
| SCHEMBL9597788 | 0.88 | NAALAD2 (0.64) | PIN1ITGB3ITGA2BMMP2MMP8 | |
| SCHEMBL19418961 | 0.88 | NAALAD2 (0.64) | PIN1ITGB3ITGA2BMMP2MMP8 | |
| SCHEMBL24533898 | 0.88 | PIN1 (0.59) | PIN1ITGB3ITGA2BHDAC2HDAC8 | |
| SCHEMBL236526 | 0.87 | KMT2A (0.58) | KMT2AITGB3ITGA2BMMP2NAALAD2 | |
| SCHEMBL6249937 | 0.87 | KMT2A (0.58) | KMT2AITGB3ITGA2BMMP2NAALAD2 | |
| SCHEMBL5272643 | 0.87 | ALDH1A1 (0.58) | KMT2APIN1ITGB3ITGA2BHDAC2 | |
| SCHEMBL6249941 | 0.87 | KMT2A (0.58) | KMT2AITGB3ITGA2BMMP2NAALAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114306297-A | Proteasome inhibitors and uses thereof | 康奈尔大学 | 2022-04-12 | — | — | CN | disclosed |
| CN-108351169-B | Proteasome inhibitors and uses thereof | 康奈尔大学 | 2022-01-28 | — | — | CN | disclosed |
| CN-108351169-A | Proteasome inhibitors and uses thereof | 康奈尔大学 | 2018-07-31 | — | — | CN | disclosed |