Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PTPRB | P23467 | 1/20 | 0.46 |
| ▸ | TOP2A | P11388 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RHEB | Q15382 | 2/20 | 0.31 |
| ▸ | FABP3 | P05413 | 1/20 | 0.30 |
| ▸ | FABP4 | P15090 | 1/20 | 0.30 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2824409 | 0.98 | HSD17B10 (0.44) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL2823399 | 0.85 | KDM4E (0.43) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL2824407 | 0.85 | TOP2A (0.40) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL13173051 | 0.85 | TOP2A (0.40) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL13787637 | 0.83 | TOP2A (0.47) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL2825505 | 0.79 | KDM4E (0.51) | HSD17B10KDM4ECYP2C9TOP2AALDH1A1 | |
| SCHEMBL2822746 | 0.78 | HCAR2 (0.43) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL2822836 | 0.77 | LMNA (0.38) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL2824744 | 0.74 | LMNA (0.40) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB | |
| SCHEMBL2822546 | 0.74 | KDM4E (0.50) | HSD17B10KDM4ECYP3A4CYP2C9PTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137574-B | Hydroxyalkyl thiadiazole derivatives | 第一三共株式会社 | 2021-12-28 | — | — | CN | disclosed |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-08-25 | — | — | US | disclosed |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-08-25 | — | — | US | disclosed |
| EP-3356361-B1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2020-07-08 | — | — | EP | disclosed |
| EP-3356361-B1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2020-07-08 | — | — | EP | disclosed |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-02-06 | — | — | US | disclosed |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-02-06 | — | — | US | disclosed |
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-03 | — | — | US | disclosed |
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-03 | — | — | US | disclosed |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-11-15 | — | — | US | disclosed |
| EP-3356361-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-08-08 | — | — | EP | disclosed |
| EP-2226322-B1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8927588-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-06 | — | — | US | disclosed |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-03-13 | — | — | US | disclosed |
| US-8536197-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-09-17 | — | — | US | disclosed |
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-12-09 | — | — | US | disclosed |
| EP-2226322-A1 | IMIDAZOLE CARBONYL COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2010-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | TOP1, TOP2B, TOP2A | HSD17B10 177/4885KDM4E 1593/4885CYP3A4 144/4885 |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | PHYKPL, SLC34A1, PNKP | HSD17B10 1043/4885KDM4E 4253/4885CYP3A4 541/4885 |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | PHYKPL, SLC34A1, PNKP | HSD17B10 997/4885KDM4E 4583/4885CYP3A4 422/4885 |
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | HSD17B10 1828/4885KDM4E 206/4885CYP3A4 345/4885 |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | TOP1, TOP2B, TOP2A | HSD17B10 177/4885KDM4E 1593/4885CYP3A4 144/4885 |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | HSD17B10 937/4885KDM4E 211/4885CYP3A4 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.