Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20428403 | 0.86 | TP53 (0.42) | PTGS2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20420746 | 0.85 | FPR1 (0.42) | PTGS2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20420755 | 0.85 | KMT2A (0.41) | PTGS2CYP3A4KDM4EALDH1A1LMNA | |
| SCHEMBL20428408 | 0.85 | FPR1 (0.43) | PTGS2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20420765 | 0.85 | FPR1 (0.43) | PTGS2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20420809 | 0.85 | FPR1 (0.43) | PTGS2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20428327 | 0.84 | KDM4E (0.42) | PTGS2CYP3A4KDM4EALDH1A1LMNA | |
| SCHEMBL20428299 | 0.83 | PTGS2 (0.40) | PTGS2CYP3A4KDM4EALDH1A1LMNA | |
| SCHEMBL20428410 | 0.82 | TSHR (0.40) | PTGS2CYP3A4CYP1A2KDM4EALDH1A1 | |
| SCHEMBL20428368 | 0.82 | HDAC1 (0.41) | PTGS2CYP3A4CYP1A2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349959-B | 4-substituted coumarin derivative and preparation method and application thereof | 成都赜灵生物医药科技有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-108349959-A | The coumarin derivative and its preparation method and application of 4 substitutions | 贵州百灵企业集团制药股份有限公司 | 2018-07-31 | — | — | CN | disclosed |