SCHEMBL28233138

SCHEMBL28233138

COC(OC)C(=O)c1cccc(C)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.53
SLC6A2 P23975 2/20 0.50
SLC6A3 Q01959 2/20 0.50
CHRNA1 P02708 1/20 0.50
CHRNG P07510 1/20 0.50
CHRNB1 P11230 1/20 0.50
CHRNB2 P17787 1/20 0.50
CHRNB4 P30926 1/20 0.50
CHRNA3 P32297 1/20 0.50
CHRNA4 P43681 1/20 0.50
CHRND Q07001 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.47
CTNNB1 P35222 1/20 0.46
WNT3A P56704 1/20 0.46
KCNK3 O14649 3/20 0.46
KCNK9 Q9NPC2 2/20 0.46
HPGD P15428 2/20 0.46
KCNH2 Q12809 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9719861 0.81 CA12 (0.52) PARP1POLBNPC1RAB9A
SCHEMBL27850070 0.80 PARP1 (0.52) PARP1SLC6A2SLC6A3CHRNA1CHRNG
SCHEMBL13002178 0.80 CES2 (0.56) PARP1SLC6A2SLC6A3CHRNB2CHRNB4
SCHEMBL8524104 0.79 KMO (0.55) HDAC8SMN1; SMN2HPGDMEN1KMT2A
SCHEMBL25247146 0.79 PARP1 (0.59) PARP1SLC6A2SLC6A3CHRNA1CHRNG
SCHEMBL29923066 0.79 PARP1 (0.59) PARP1SLC6A2SLC6A3CHRNA1CHRNG
SCHEMBL585998 0.79 PARP1 (0.59) PARP1SLC6A2SLC6A3CHRNA1CHRNG
SCHEMBL2266455 0.78 CTNNB1 (0.51) PARP1HDAC8HDAC6SMN1; SMN2CTNNB1
SCHEMBL26712 0.78 TSHR (0.52) KCNH2MEN1KMT2ATDP1POLB
Benzene SCHEMBL27641543 0.78 TSHR (0.52) KCNH2MEN1KMT2ATDP1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108530273-A A kind of synthetic method of 2,4- dimethoxy-toluenes base -4- propyl diphenol 武汉桀升生物科技有限公司 2018-09-14 CN disclosed