Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28233689 | 0.88 | LMNA (0.57) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL28620697 | 0.80 | POLB (0.48) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL28906662 | 0.76 | RAB9A (1.00) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL28234718 | 0.76 | BRAF (0.70) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL30230060 | 0.76 | SMN1; SMN2 (0.73) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL28233679 | 0.75 | MAPT (0.56) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL28624700 | 0.75 | BRAF (0.54) | MEN1KMT2AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL17111092 | 0.75 | RAB9A (0.71) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL28241488 | 0.73 | SMN1; SMN2 (0.74) | MEN1KMT2AMAPTSMN1; SMN2LMNA | |
| SCHEMBL28614006 | 0.73 | BRAF (0.54) | MEN1KMT2AMAPTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108409663-B | Microtubule inhibitors, methods of preparation and uses thereof | 成都威斯克生物医药有限公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-108409663-A | Microtubule inhibitors and its preparation method and application | 四川大学 | 2018-08-17 | — | — | CN | disclosed |