Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.49 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823380 | 1.00 | HSD11B1 (0.49) | HSD11B1HSD11B2STSEPHX2PKM | |
| SCHEMBL2826231 | 0.90 | HSD11B1 (0.40) | HSD11B1HSD11B2STSEPHX2PKM | |
| SCHEMBL2826225 | 0.90 | HSD11B1 (0.40) | HSD11B1HSD11B2STSEPHX2PKM | |
| SCHEMBL2824155 | 0.89 | HSD11B1 (0.47) | HSD11B1HSD11B2EPHX2USP30 | |
| SCHEMBL2824153 | 0.89 | HSD11B1 (0.47) | HSD11B1HSD11B2EPHX2USP30 | |
| SCHEMBL2823628 | 0.83 | HSD11B1 (0.45) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL2823635 | 0.83 | HSD11B1 (0.45) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL2823676 | 0.83 | HSD11B1 (0.52) | HSD11B1HSD11B2EPHX2USP30 | |
| SCHEMBL2823671 | 0.83 | HSD11B1 (0.52) | HSD11B1HSD11B2EPHX2USP30 | |
| SCHEMBL2827939 | 0.82 | HSD11B1 (0.56) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |