Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 5/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826225 | 1.00 | HSD11B1 (0.40) | HSD11B1STSHSD11B2EPHX2CNR2 | |
| SCHEMBL2823380 | 0.90 | HSD11B1 (0.49) | HSD11B1STSHSD11B2EPHX2CNR2 | |
| SCHEMBL2823388 | 0.90 | HSD11B1 (0.49) | HSD11B1STSHSD11B2EPHX2CNR2 | |
| SCHEMBL2826370 | 0.89 | HSD11B1 (0.38) | HSD11B1STSHSD11B2EPHX2CNR2 | |
| SCHEMBL2826372 | 0.89 | HSD11B1 (0.38) | HSD11B1STSHSD11B2EPHX2CNR2 | |
| SCHEMBL2823974 | 0.81 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2823970 | 0.81 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2824714 | 0.81 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2824721 | 0.81 | HSD11B1 (0.47) | HSD11B1HSD11B2 | |
| SCHEMBL2826228 | 0.80 | SIGMAR1 (0.41) | HSD11B1HSD11B2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |