Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 5/20 | 0.33 |
| ▸ | GPR6 | P46095 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824621 | 0.90 | HSD11B1 (0.43) | SIGMAR1HSD11B1HSD11B2GPR6MEN1 | |
| SCHEMBL2824481 | 0.81 | GPR6 (0.33) | SIGMAR1GPR6GCKP2RX7 | |
| SCHEMBL2823973 | 0.81 | HSD11B1 (0.39) | HSD11B1HSD11B2P2RX7 | |
| SCHEMBL2824719 | 0.80 | HSD11B1 (0.38) | HSD11B1HSD11B2P2RX7 | |
| SCHEMBL2823391 | 0.79 | HSD11B1 (0.38) | HSD11B1SLC6A3HSD11B2GPR6MEN1 | |
| SCHEMBL2823390 | 0.79 | HSD11B1 (0.38) | HSD11B1SLC6A3HSD11B2GPR6MEN1 | |
| SCHEMBL2826228 | 0.78 | SIGMAR1 (0.41) | SIGMAR1HSD11B1HSD11B2P2RX7 | |
| SCHEMBL2824913 | 0.78 | HSD11B1 (0.41) | SIGMAR1HSD11B1HSD11B2 | |
| SCHEMBL2825680 | 0.77 | HSD11B1 (0.55) | HSD11B1HSD11B2 | |
| SCHEMBL2822936 | 0.77 | HSD11B1 (0.55) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |