Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28235922 | 0.68 | L3MBTL1 (0.59) | ALDH1A1CSF1RLMNAL3MBTL1 | |
| SCHEMBL28242755 | 0.67 | NPC1 (0.59) | CD38SMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL2984435 | 0.67 | L3MBTL1 (0.70) | HPGDSMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2998695 | 0.67 | L3MBTL1 (0.70) | HPGDSMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL26401026 | 0.67 | KMT2A (0.71) | CD38HPGDSMN1; SMN2TSHRHTR2A | |
| SCHEMBL2998723 | 0.65 | L3MBTL1 (0.68) | HPGDSMN1; SMN2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL28235923 | 0.65 | HPGD (0.72) | HPGDSMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL8808479 | 0.64 | HRH3 (0.54) | ALDH1A1HTR2AHTR2CHTR2BHRH3 | |
| SCHEMBL25135727 | 0.64 | CD38 (0.61) | CD38HPGDALDH1A1L3MBTL1 | |
| SCHEMBL30040534 | 0.64 | CD38 (1.00) | CD38 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108586439-A | A kind of Raf kinase and its application in treatment of cancer | 刘思良 | 2018-09-28 | — | — | CN | disclosed |
| CN-108484587-A | A kind of Raf kinase and its application in treatment of cancer | 刘思良 | 2018-09-04 | — | — | CN | disclosed |
| CN-108456186-A | A kind of Raf kinase and its application in treatment of cancer | 刘思良 | 2018-08-28 | — | — | CN | disclosed |