Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31092664 | 0.82 | AXL (0.45) | NOS2HTR2AHTR2CHTR2BLMNA | |
| SCHEMBL8810828 | 0.81 | HRH3 (0.62) | HRH3POLBKDM4EALDH1A1PKM | |
| SCHEMBL8810497 | 0.81 | HRH3 (0.54) | HRH3POLBKDM4EALDH1A1PKM | |
| SCHEMBL18098542 | 0.80 | ACHE (0.62) | HRH3POLBNOTUMROCK2KAT2B | |
| SCHEMBL8818072 | 0.77 | HRH3 (0.60) | HRH3POLBKDM4EALDH1A1PKM | |
| SCHEMBL10953965 | 0.76 | HRH3 (0.88) | HRH3POLBKDM4EALDH1A1PKM | |
| SCHEMBL5863541 | 0.75 | HRH3 (0.67) | HRH3POLBKDM4EALDH1A1PKM | |
| SCHEMBL8811827 | 0.75 | HRH3 (0.54) | HRH3POLBKDM4EALDH1A1PKM | |
| SCHEMBL9056638 | 0.75 | HRH3 (0.54) | HRH3POLBKDM4EALDH1A1PKM | |
| SCHEMBL9062963 | 0.75 | HRH3 (0.54) | HRH3POLBKDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |