Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | CTSC | P53634 | 2/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL5503058 | 0.87 | SLC7A5 (0.34) | PTPN1SLC7A5ITGB3ITGA2BHTR2C | |
| Tyrosine SCHEMBL28644593 | 0.86 | SLC7A5 (0.35) | SLC7A5HTR2CHTR2BDPP4KDM4E | |
| Tyrosine SCHEMBL20575032 | 0.85 | SLC7A5 (0.52) | SLC7A5PTGS1CTSCALPIPKM | |
| Proline SCHEMBL17728310 | 0.85 | PTPN1 (0.43) | PTPN1SLC7A5ITGB3ITGA2BHTR2C | |
| SCHEMBL9346887 | 0.84 | SLC7A5 (0.51) | PTPN1SLC7A5ITGB3ITGA2BPTGS1 | |
| SCHEMBL6046921 | 0.84 | SLC7A5 (0.51) | PTPN1SLC7A5ITGB3ITGA2BPTGS1 | |
| SCHEMBL4542258 | 0.82 | PTPN1 (0.45) | PTPN1SLC7A5ITGB3ITGA2BHTR2C | |
| SCHEMBL6284117 | 0.82 | SLC7A5 (0.46) | PTPN1SLC7A5ITGB3ITGA2BHTR2C | |
| SCHEMBL28044415 | 0.81 | PTPN1 (0.43) | PTPN1SLC7A5ITGB3ITGA2BPTGS1 | |
| Cystine SCHEMBL7594899 | 0.80 | SLC7A5 (0.46) | SLC7A5PTGS1CTSCALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473970-A | DNA polymerase variants | 国立大学法人九州大学 | 2018-08-31 | — | — | CN | disclosed |