Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | CTSC | P53634 | 3/20 | 0.32 |
| ▸ | TPH1 | P17752 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | ALPI | P09923 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL4188697 | 0.90 | ITGB3 (0.30) | ITGB3ITGA2B | |
| Proline SCHEMBL28237451 | 0.87 | PTPN1 (0.38) | SLC7A5PTPN1ITGB3ITGA2BHTR2C | |
| Leucine SCHEMBL17065117 | 0.83 | REN (0.33) | — | |
| Tyrosine SCHEMBL28644593 | 0.83 | SLC7A5 (0.35) | SLC7A5HTR2CHTR2BDPP4KDM4E | |
| Leucine SCHEMBL5151721 | 0.83 | REN (0.34) | — | |
| Glutamine SCHEMBL8134265 | 0.81 | ALOX15 (0.47) | SLC7A5PTPN1ITGB3ITGA2BTPH1 | |
| Tyrosine SCHEMBL28179550 | 0.80 | SLC7A5 (0.51) | SLC7A5DPP4CTSCTPH1PTGS1 | |
| Phenylalanine SCHEMBL15901818 | 0.80 | SLC7A5 (0.49) | SLC7A5HTR2CHTR2BDPP4CTSC | |
| Histidine SCHEMBL8084688 | 0.80 | — | — | |
| Proline SCHEMBL17728310 | 0.79 | PTPN1 (0.43) | SLC7A5PTPN1ITGB3ITGA2BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1779393-A1 | ANTISTATIC AGENT, ANTISTATIC FILM AND PRODUCT COATED WITH ANTISTATIC FILM | SHOWA DENKO KABUSHIKI KAISHA (JP) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006016670-A1 | ANTISTATIC AGENT, ANTISTATIC FILM AND PRODUCT COATED WITH ANTISTATIC FILM | SHOWA DENKO K.K. (JP) | 2006-02-16 | — | — | WO | disclosed |