SCHEMBL28239019

SCHEMBL28239019

Cc1ncccc1CC(=O)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 1/20 0.49
WNT3A P56704 1/20 0.49
CYP2C9 P11712 2/20 0.47
NAMPT P43490 1/20 0.47
KDM4E B2RXH2 4/20 0.44
MAPT P10636 4/20 0.44
CYP1A2 P05177 3/20 0.44
PLOD2 O00469 2/20 0.44
RAB9A P51151 5/20 0.43
ALDH1A1 P00352 5/20 0.43
NPC1 O15118 4/20 0.43
KMT2A Q03164 3/20 0.43
CYP2C19 P33261 2/20 0.43
CYP3A4 P08684 2/20 0.43
HPGD P15428 2/20 0.43
MEN1 O00255 2/20 0.43
PLOD3 O60568 1/20 0.43
CYP2D6 P10635 1/20 0.43
PLOD1 Q02809 1/20 0.43
HIF1A Q16665 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14676404 0.86 PTGDR2 (0.46) CYP2C9NAMPTKDM4EMAPTCYP1A2
SCHEMBL575046 0.82 KDM4E (0.62) CYP2C9NAMPTKDM4EMAPTCYP1A2
Hydrochloric Acid SCHEMBL3725590 0.81 KDM4E (0.61) CYP2C9NAMPTKDM4EMAPTCYP1A2
SCHEMBL27850638 0.80 CTNNB1 (0.49) CTNNB1WNT3ACYP2C9KDM4EMAPT
SCHEMBL13568063 0.79 P2RX7 (0.47) CYP2C9NAMPTKDM4EMAPTCYP1A2
SCHEMBL7196858 0.78 MAPT (0.61) CYP2C9KDM4EMAPTCYP1A2PLOD2
SCHEMBL999250 0.77 P2RX7 (0.50) CYP2C9NAMPTKDM4EMAPTCYP1A2
SCHEMBL159113 0.77 ALDH1A1 (0.56) KDM4EMAPTRAB9AALDH1A1NPC1
Hydrochloric Acid SCHEMBL27586436 0.75 ALDH1A1 (0.54) KDM4EMAPTRAB9AALDH1A1NPC1
Acetic Acid SCHEMBL28688767 0.75 P2RX7 (0.47) CYP2C9NAMPTKDM4EMAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108440527-A A kind of acidification corrosion inhibitor and the preparation method and application thereof based on mutual aggressiveness indole derivative 中国石油大学(华东) 2018-08-24 CN disclosed