Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.60 |
| ▸ | HTT | P42858 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685900 | 0.92 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL28538675 | 0.89 | POLB (0.67) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL28910238 | 0.89 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL4363865 | 0.89 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL28542658 | 0.88 | ALDH1A1 (0.79) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL28530566 | 0.88 | LTB4R (0.52) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL28525408 | 0.85 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL28537086 | 0.85 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A | |
| SCHEMBL28536514 | 0.84 | BCHE (0.50) | MAPTPOLBL3MBTL1 | |
| SCHEMBL797463 | 0.80 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2HTTMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108358923-B | Sophoridine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | claimed |
| CN-108358923-A | Sophoridine pyrroles, indole derivatives and the preparation method and application thereof | 广西大学 | 2018-08-03 | — | — | CN | claimed |
| CN-108358923-B | Sophoridine pyrrole and indole derivatives, and preparation method and application thereof | 广西大学 | 2020-11-03 | — | — | CN | disclosed |
| CN-108358923-A | Sophoridine pyrroles, indole derivatives and the preparation method and application thereof | 广西大学 | 2018-08-03 | — | — | CN | disclosed |