Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8373056 | 0.86 | HPGD (0.72) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL18715343 | 0.86 | HPGD (0.79) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL29617700 | 0.82 | HPGD (0.64) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL7847972 | 0.82 | LMNA (0.64) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL18641858 | 0.82 | HPGD (0.64) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL28409688 | 0.80 | HPGD (0.67) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL23136224 | 0.79 | GAA (0.60) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL30989963 | 0.79 | HPGD (0.65) | HPGDLMNASMN1; SMN2MAPK8KMT2A | |
| SCHEMBL28239383 | 0.79 | HPGD (0.78) | HPGDLMNASMN1; SMN2KMT2APOLB | |
| SCHEMBL28239389 | 0.78 | EGLN1 (0.60) | HPGDSMN1; SMN2MAPK8KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108431007-A | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | 洛克索肿瘤学股份有限公司 | 2018-08-21 | — | — | CN | disclosed |