Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.60 |
| ▸ | NSD2 | O96028 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983554 | 0.88 | EGLN1 (0.76) | EGLN1NSD2NPC1RAB9AKMT2A | |
| SCHEMBL15447128 | 0.82 | EGLN1 (0.57) | EGLN1NSD2NPC1RAB9AKMT2A | |
| SCHEMBL12186787 | 0.82 | HDAC6 (0.68) | EGLN1 | |
| SCHEMBL29617730 | 0.82 | EGLN1 (0.57) | EGLN1NSD2NPC1RAB9AKMT2A | |
| SCHEMBL18641961 | 0.82 | EGLN1 (0.57) | EGLN1NSD2NPC1RAB9AKMT2A | |
| SCHEMBL28870593 | 0.79 | HDAC2 (0.66) | NSD2KMT2AHPGD | |
| SCHEMBL4969813 | 0.78 | ALDH1A1 (0.64) | EGLN1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL28239376 | 0.78 | HPGD (0.63) | KMT2AMEN1MAPTMAPK8HPGD | |
| Hydrochloric Acid SCHEMBL4062177 | 0.76 | PARP1 (0.59) | EGLN1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7382937 | 0.76 | EGLN1 (0.74) | EGLN1NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108431007-A | PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER | 洛克索肿瘤学股份有限公司 | 2018-08-21 | — | — | CN | disclosed |