Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL137486 | 0.72 | TDP1 (0.83) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| SCHEMBL8511596 | 0.71 | SMN1; SMN2 (0.54) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| SCHEMBL14369841 | 0.70 | TDP1 (0.61) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| SCHEMBL547137 | 0.70 | TDP1 (0.79) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| SCHEMBL13292516 | 0.70 | TDP1 (0.79) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| SCHEMBL16217656 | 0.70 | TDP1 (0.79) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| SCHEMBL28286830 | 0.70 | TDP1 (0.79) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| SCHEMBL1449565 | 0.69 | TDP1 (0.70) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| Ethylene SCHEMBL7587624 | 0.69 | TDP1 (0.76) | SMN1; SMN2TDP1LMNAMAPK1HIF1A | |
| Ethylene SCHEMBL11578922 | 0.69 | TDP1 (0.76) | SMN1; SMN2TDP1LMNAMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008371-B | Macrocyclic pyridazinone derivatives | 默克专利股份公司 | 2018-09-18 | — | — | CN | disclosed |