Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10875900 | 0.81 | EGFR (0.54) | EGFRPOLBNR2F2CCNB2CDK1 | |
| SCHEMBL32669328 | 0.77 | EGFR (0.51) | EGFRPOLBNR2F2CCNB2CDK1 | |
| SCHEMBL32669313 | 0.76 | CDK1 (0.51) | EGFRPOLBNR2F2CCNB2CDK1 | |
| SCHEMBL18786736 | 0.75 | HTT (0.56) | EGFRPOLBNR2F2CCNB2CDK1 | |
| SCHEMBL27429524 | 0.75 | VNN1 (0.61) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL5605226 | 0.73 | RAB9A (0.58) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL27088969 | 0.71 | CCNE2 (0.46) | EGFRPOLBNR2F2CCNB2CDK1 | |
| SCHEMBL27088974 | 0.71 | CCNE2 (0.46) | EGFRPOLBNR2F2CCNB2CDK1 | |
| SCHEMBL29998666 | 0.71 | CCNE2 (0.46) | EGFRPOLBNR2F2CCNB2CDK1 | |
| SCHEMBL7951301 | 0.70 | VNN1 (0.50) | EGFRPOLBNR2F2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602805-A | Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |