Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127484 | 0.81 | EGFR (0.50) | VNN1EGFRNR2F2APPMEN1 | |
| SCHEMBL5823848 | 0.78 | APP (0.60) | VNN1EGFRPOLBNR2F2APP | |
| SCHEMBL27429524 | 0.78 | VNN1 (0.61) | VNN1EGFRPOLBNR2F2MEN1 | |
| SCHEMBL29975310 | 0.76 | EGFR (0.61) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL29911298 | 0.74 | MEN1 (0.52) | VNN1EGFRAPPMEN1KMT2A | |
| SCHEMBL18571985 | 0.74 | MEN1 (0.52) | VNN1EGFRAPPMEN1KMT2A | |
| SCHEMBL21046947 | 0.73 | VNN1 (0.64) | VNN1APPMEN1KMT2ACLK4 | |
| SCHEMBL25934362 | 0.73 | VNN1 (0.64) | VNN1MEN1KMT2ACLK4CLK1 | |
| SCHEMBL5605226 | 0.73 | RAB9A (0.58) | VNN1EGFRPOLBNR2F2MEN1 | |
| SCHEMBL2360492 | 0.73 | APP (0.60) | VNN1POLBAPPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001517226-A | — | — | 2001-10-02 | — | — | JP | claimed |
| EP-0971925-A1 | PYRIMIDOPYRIMIDINE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998043974-A1 | PYRIMIDOPYRIMIDINE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-10-08 | — | — | WO | claimed |