Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 16/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 16/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21808436 | 0.91 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL288665 | 0.91 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1PTGS1ALDH1A1 | |
| SCHEMBL30185566 | 0.81 | CPN1 (0.42) | AKR1C3AKR1C2ALDH1A1MEN1KMT2A | |
| SCHEMBL6298061 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3674481 | 0.78 | MEN1 (0.61) | AKR1C3AKR1C2AKR1C1AKR1B10AKR1C4 | |
| SCHEMBL11109035 | 0.77 | PARP1 (0.49) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5021484 | 0.77 | CPN1 (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL28040963 | 0.76 | L3MBTL1 (0.40) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL1492705 | 0.76 | CTSK (0.46) | ALDH1A1 | |
| SCHEMBL2016833 | 0.75 | AKR1C3 (0.51) | AKR1C3AKR1C2AKR1C1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602805-A | Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |