Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28293694 | 0.74 | ACHE (0.40) | ACHEALDH1A1CES1CES2NPC1 | |
| SCHEMBL27509682 | 0.73 | APP (0.45) | APPACHEALDH1A1KDM4EGAA | |
| SCHEMBL28000444 | 0.71 | APP (0.41) | APPACHEALDH1A1KDM4EGAA | |
| SCHEMBL27493876 | 0.68 | ALDH1A1 (0.41) | APPALDH1A1KDM4EGAAMAPT | |
| Ethyne SCHEMBL9049731 | 0.67 | APP (0.67) | APPALDH1A1KDM4EGAAMAPT | |
| SCHEMBL28120002 | 0.67 | APP (0.38) | APPACHEESR1ESR2TAAR1 | |
| SCHEMBL13338132 | 0.66 | APP (0.52) | APPACHEALDH1A1KDM4EGAA | |
| SCHEMBL59001 | 0.66 | APP (0.73) | APPACHEALDH1A1KDM4EGAA | |
| SCHEMBL4305587 | 0.64 | APP (0.44) | APPACHEALDH1A1KDM4EGAA | |
| SCHEMBL28018693 | 0.64 | CES2 (0.50) | ACHEALDH1A1CES1CES2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109761944-A | A kind of chrysin amide derivatives and preparation method thereof and medical usage | 武汉翼博济生生物科技有限公司 | 2019-05-17 | — | — | CN | disclosed |
| CN-104918615-B | The method for treating hepatopathy | 扎夫根股份有限公司 | 2018-10-12 | — | — | CN | disclosed |