Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827526 | 0.75 | HSD11B1 (0.43) | HSD11B1JAK3 | |
| SCHEMBL2827531 | 0.75 | HSD11B1 (0.43) | HSD11B1JAK3 | |
| SCHEMBL2827525 | 0.75 | HSD11B1 (0.43) | HSD11B1JAK3 | |
| SCHEMBL2827530 | 0.74 | P2RX7 (0.35) | HSD11B1LMNAJAK3ALDH1A1KCNMA1 | |
| SCHEMBL2827165 | 0.73 | HSD11B1 (0.34) | HSD11B1 | |
| SCHEMBL2824066 | 0.73 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL2824511 | 0.71 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL2828163 | 0.70 | HSD11B1 (0.32) | HSD11B1 | |
| SCHEMBL2827173 | 0.67 | P2RX7 (0.32) | LMNAGAANPSR1 | |
| SCHEMBL2827581 | 0.66 | HSD11B1 (0.40) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |