Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL28246712

COc1ccc(NC(=S)Nc2ccccc2)cc1.S

nearest known ligand 0.96

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.96
CYP2C19 P33261 2/20 0.96
ALDH1A1 P00352 5/20 0.81
MAPT P10636 4/20 0.81
KMT2A Q03164 2/20 0.81
MEN1 O00255 1/20 0.81
HTT P42858 1/20 0.81
MAOB P27338 3/20 0.69
MAOA P21397 2/20 0.69
HPGD P15428 1/20 0.68
NPC1 O15118 4/20 0.67
RAB9A P51151 4/20 0.67
SMN1; SMN2 Q16637 2/20 0.67
CYP3A4 P08684 2/20 0.67
CYP2C9 P11712 1/20 0.67
NPSR1 Q6W5P4 1/20 0.65
GAA P10253 2/20 0.65
TAS2R38 P59533 1/20 0.63
HSD17B10 Q99714 1/20 0.63
TDP1 Q9NUW8 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1259295 0.98 CYP1A2 (1.00) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL8167087 0.90 CYP1A2 (0.85) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL16639672 0.83 CYP1A2 (0.73) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL18031168 0.83 CYP1A2 (0.73) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL7028772 0.82 KMT2A (0.77) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL8956322 0.82 ALDH1A1 (0.94) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL11683119 0.81 SMN1; SMN2 (0.79) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL6578291 0.81 ALDH1A1 (0.80) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL12177297 0.81 HPGD (1.00) CYP1A2CYP2C19ALDH1A1MAPTKMT2A
SCHEMBL1884695 0.81 MAOB (0.73) CYP1A2CYP2C19ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108541253-A The method for producing 5 hydroxymethyl furfural in the presence of at least one aprotic polar solvent in the presence of lewis acid catalyst and/or multiphase base catalyst and homogeneous organic bronsted acid catalyst IFP 新能源公司 2018-09-14 CN disclosed