Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827996 | 0.88 | KMT2A (0.47) | KMT2AGAAEGFRGRM5ALDH1A1 | |
| SCHEMBL2830984 | 0.87 | ALDH1A1 (0.50) | KMT2AALDH1A1HPGDKDRFLT1 | |
| SCHEMBL2829084 | 0.86 | HPGD (0.48) | KMT2AALDH1A1HPGDRAB9AMEN1 | |
| SCHEMBL2828100 | 0.86 | NPC1 (0.46) | KMT2AGAAALDH1A1HPGDCDK8 | |
| SCHEMBL2828820 | 0.82 | KMT2A (0.42) | KMT2AGAAEGFRGRM5ALDH1A1 | |
| SCHEMBL2829765 | 0.82 | KMT2A (0.43) | KMT2AGAAEGFRGRM5ALDH1A1 | |
| SCHEMBL2828420 | 0.80 | GRK2 (0.44) | KMT2AEGFRGRM5ALDH1A1KDR | |
| SCHEMBL2828557 | 0.80 | KDM4E (0.43) | KMT2AGAAEGFRGRM5ALDH1A1 | |
| SCHEMBL2830799 | 0.78 | ALDH1A1 (0.46) | KMT2AALDH1A1HPGDKDRFLT1 | |
| SCHEMBL2827909 | 0.77 | MAPT (0.47) | KMT2AHPGDRAB9AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |