Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827909 | 0.90 | MAPT (0.47) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2829161 | 0.88 | HPGD (0.50) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2830984 | 0.87 | ALDH1A1 (0.50) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2830058 | 0.87 | LMNA (0.50) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2824772 | 0.86 | KMT2A (0.45) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2828100 | 0.86 | NPC1 (0.46) | HPGDMAPTMEN1KMT2ALMNA | |
| SCHEMBL2827687 | 0.85 | MEN1 (0.49) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2826420 | 0.83 | LMNA (0.47) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2826665 | 0.82 | HPGD (0.50) | HPGDALOX15MAPTMEN1KMT2A | |
| SCHEMBL2826660 | 0.82 | LMNA (0.46) | HPGDALOX15MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |