Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826544 | 0.89 | ALDH1A1 (0.46) | KDM4EKMT2AALDH1A1HPGDMAPT | |
| SCHEMBL2828787 | 0.88 | MAPT (0.47) | KMT2AALDH1A1HPGDMAPTLMNA | |
| SCHEMBL2828820 | 0.82 | KMT2A (0.42) | KDM4EKMT2AEGFRGAAGRM5 | |
| SCHEMBL2827996 | 0.82 | KMT2A (0.47) | KDM4EKMT2AEGFRGAAGRM5 | |
| SCHEMBL2824772 | 0.80 | KMT2A (0.45) | KDM4EKMT2AEGFRGAAGRM5 | |
| SCHEMBL2829765 | 0.76 | KMT2A (0.43) | KDM4EKMT2AEGFRGAAGRM5 | |
| SCHEMBL2828420 | 0.74 | GRK2 (0.44) | KMT2AEGFRGRM5ALDH1A1MAPT | |
| SCHEMBL2829103 | 0.74 | SMN1; SMN2 (0.47) | KDM4EKMT2AALDH1A1MAPTLMNA | |
| SCHEMBL2830832 | 0.73 | ALDH1A1 (0.49) | KDM4EKMT2AALDH1A1HPGDMAPT | |
| SCHEMBL2827571 | 0.71 | LMNA (0.47) | KMT2AALDH1A1HPGDLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |