Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28495073 | 1.00 | DNM1 (0.43) | DNM1LMNAPOLBSMN1; SMN2MAPK1 | |
| Bromide SCHEMBL28502550 | 1.00 | DNM1 (0.43) | DNM1LMNAPOLBSMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL28247903 | 0.96 | DNM1 (0.43) | DNM1LMNAPOLBSMN1; SMN2MAPK1 | |
| Iodide SCHEMBL27860071 | 0.96 | DNM1 (0.40) | DNM1LMNAPOLBSMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL27876627 | 0.96 | DNM1 (0.43) | DNM1LMNAPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL4723915 | 0.90 | LMNA (0.40) | LMNAPOLBSMN1; SMN2MAPK1ALDH1A1 | |
| Bromide SCHEMBL28309885 | 0.83 | DNM1 (0.40) | DNM1LMNAPOLBSMN1; SMN2MAPK1 | |
| Bromide SCHEMBL28875153 | 0.83 | DNM1 (0.40) | DNM1LMNAPOLBSMN1; SMN2MAPK1 | |
| SCHEMBL4724117 | 0.82 | SMN1; SMN2 (0.34) | LMNAPOLBSMN1; SMN2MAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28309112 | 0.79 | DNM1 (0.40) | DNM1LMNAPOLBSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707131-B | Application method of catalyst for synthesizing cyclic carbonate based on normal temperature and pressure | 武汉艾奥立化学科技有限公司 | 2020-12-04 | — | — | CN | disclosed |
| CN-108707131-A | A kind of application process based on the catalyst of synthesizing annular carbonate under normal temperature and pressure | 武汉艾奥立化学科技有限公司 | 2018-10-26 | — | — | CN | disclosed |