Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28309885 | 1.00 | DNM1 (0.40) | DNM1HTTKMT2AMEN1MLYCD | |
| Hydrochloric Acid SCHEMBL28309131 | 0.96 | DNM1 (0.40) | DNM1HTTKMT2AMEN1MLYCD | |
| Hydrochloric Acid SCHEMBL28309047 | 0.96 | DNM1 (0.40) | DNM1HTTKMT2AMEN1MLYCD | |
| Hydrochloric Acid SCHEMBL28309112 | 0.96 | DNM1 (0.40) | DNM1HTTKMT2AMEN1MLYCD | |
| SCHEMBL4720873 | 0.90 | LMNA (0.37) | HTTKMT2AMEN1MLYCDTSHR | |
| SCHEMBL4721519 | 0.86 | LMNA (0.35) | HTTKMT2AMEN1MLYCDSMN1; SMN2 | |
| SCHEMBL4719946 | 0.84 | POLB (0.36) | HTTKMT2AMEN1MLYCDSMN1; SMN2 | |
| Bromide SCHEMBL28495073 | 0.83 | DNM1 (0.43) | DNM1HTTKMT2AMEN1MLYCD | |
| Bromide SCHEMBL28502550 | 0.83 | DNM1 (0.43) | DNM1HTTKMT2AMEN1MLYCD | |
| Bromide SCHEMBL28247889 | 0.83 | DNM1 (0.43) | DNM1HTTKMT2AMEN1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107442288-B | A kind of morpholine quaternary ammonium salt Gemini surface active for mineral floating | 江西理工大学 | 2019-08-06 | — | — | CN | disclosed |