SCHEMBL28249147

SCHEMBL28249147

O=C(Nc1cccc2cccnc12)c1cccc(C(F)(F)F)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.67
KDR P35968 4/20 0.67
NPC1 O15118 2/20 0.67
L3MBTL1 Q9Y468 2/20 0.67
MEN1 O00255 2/20 0.67
KMT2A Q03164 2/20 0.67
HTT P42858 1/20 0.63
CASP3 P42574 1/20 0.62
SENP8 Q96LD8 1/20 0.62
SENP7 Q9BQF6 1/20 0.62
SENP6 Q9GZR1 1/20 0.62
HDAC6 Q9UBN7 1/20 0.61
SLC40A1 Q9NP59 1/20 0.60
GAA P10253 3/20 0.60
PTGS1 P23219 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
MAPT P10636 3/20 0.59
TP53 P04637 1/20 0.59
LMNA P02545 1/20 0.59
BRAF P15056 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30733198 1.00 RAB9A (0.67) RAB9AKDRNPC1L3MBTL1MEN1
SCHEMBL19748451 0.88 HDAC6 (0.73) RAB9AKDRNPC1L3MBTL1MEN1
SCHEMBL29655108 0.88 HDAC6 (0.73) RAB9AKDRNPC1L3MBTL1MEN1
SCHEMBL3941624 0.84 KMT2A (0.67) RAB9ANPC1KMT2AGAAPTGS1
SCHEMBL19422867 0.83 KDR (0.72) RAB9AKDRNPC1L3MBTL1MEN1
SCHEMBL29911021 0.83 KDR (0.72) RAB9AKDRNPC1L3MBTL1MEN1
SCHEMBL22441865 0.83 MEN1 (0.55) RAB9AKDRNPC1L3MBTL1MEN1
SCHEMBL22441862 0.83 MEN1 (0.55) RAB9AKDRNPC1L3MBTL1MEN1
SCHEMBL29911165 0.83 GAA (0.64) RAB9ANPC1MEN1KMT2AHTT
SCHEMBL17552192 0.83 GAA (0.64) RAB9ANPC1MEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113527258-A Optically pure amine compound and preparation method and application thereof 西北工业大学 2021-10-22 CN claimed
CN-108752186-B Preparation method of 2-benzyl-5-trifluoromethylbenzoic acid 安徽古尔特科技有限公司 2021-03-19 CN claimed
CN-108752186-A A kind of preparation method of 2- benzyls -5- trifluoromethylbenzoic acids 安徽古尔特科技有限公司 2018-11-06 CN claimed
CN-113527258-A Optically pure amine compound and preparation method and application thereof 西北工业大学 2021-10-22 CN disclosed
CN-108752186-B Preparation method of 2-benzyl-5-trifluoromethylbenzoic acid 安徽古尔特科技有限公司 2021-03-19 CN disclosed
CN-108752186-B Preparation method of 2-benzyl-5-trifluoromethylbenzoic acid 安徽古尔特科技有限公司 2021-03-19 CN disclosed
CN-109320497-B Method for preparing phenanthridinone compound by copper compound induction 广州大学 2020-07-31 CN disclosed
CN-109320497-A A method of phenanthridines ketone compounds are prepared by copper compound induction 广州大学 2019-02-12 CN disclosed
CN-108752186-A A kind of preparation method of 2- benzyls -5- trifluoromethylbenzoic acids 安徽古尔特科技有限公司 2018-11-06 CN disclosed
CN-108752186-A A kind of preparation method of 2- benzyls -5- trifluoromethylbenzoic acids 安徽古尔特科技有限公司 2018-11-06 CN disclosed