Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | NNMT | P40261 | 1/20 | 0.65 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.62 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.62 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.62 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.62 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868569 | 0.87 | RAB9A (0.74) | KMT2ANNMTKCNQ3KCNQ2KCNE1 | |
| SCHEMBL30733198 | 0.84 | RAB9A (0.67) | KMT2AGAAPTGS1NPC1RAB9A | |
| SCHEMBL3933821 | 0.84 | KCNQ3 (0.64) | KMT2AKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL28249147 | 0.84 | RAB9A (0.67) | KMT2AGAAPTGS1NPC1RAB9A | |
| SCHEMBL14082710 | 0.83 | RAB9A (0.58) | KMT2ANNMTNPC1RAB9APOLB | |
| SCHEMBL3941645 | 0.82 | GAA (0.62) | GAAPTGS1POLBTLR7ALDH1A1 | |
| SCHEMBL31606898 | 0.82 | ALDH1A1 (0.62) | GAAPTGS1TLR7ALDH1A1BRAF | |
| SCHEMBL31606915 | 0.80 | SCN5A (0.58) | KMT2AKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL15492250 | 0.80 | KMT2A (0.71) | KMT2ANPC1RAB9APOLBALDH1A1 | |
| SCHEMBL4168687 | 0.79 | CSF1R (0.72) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |