Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.96 |
| ▸ | DRD3 | P35462 | 8/20 | 0.96 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.96 |
| ▸ | HTR1A | P08908 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | HTR3A | P46098 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.51 |
| ▸ | HTR3B | O95264 | 1/20 | 0.51 |
| ▸ | NCF1 | P14598 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28169968 | 0.98 | DRD2 (0.93) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| SCHEMBL6352699 | 0.98 | DRD2 (1.00) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| SCHEMBL8511 | 0.98 | DRD2 (1.00) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| SCHEMBL29367982 | 0.98 | DRD2 (1.00) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL29470848 | 0.96 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Bromide SCHEMBL981906 | 0.96 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL2217039 | 0.96 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL246338 | 0.96 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| SCHEMBL3609605 | 0.91 | DRD2 (0.87) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL253371 | 0.90 | DRD2 (0.84) | DRD2DRD3ADRB1HTR1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108771680-A | The application of [4- (2,3- dichlorophenyls) piperazine -1- bases] benzimidazole and thiazole methyl ketone | 马韫韬 | 2018-11-09 | — | — | CN | disclosed |