Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 1.00 |
| ▸ | DRD3 | P35462 | 8/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 4/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | HTR3A | P46098 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | HTR6 | P50406 | 2/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29367982 | 1.00 | DRD2 (1.00) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| SCHEMBL6352699 | 1.00 | DRD2 (1.00) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL2217039 | 0.98 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL29470848 | 0.98 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Bromide SCHEMBL981906 | 0.98 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL246338 | 0.98 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Piperazine SCHEMBL28251276 | 0.98 | DRD2 (0.96) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Piperazine SCHEMBL28169968 | 0.96 | DRD2 (0.93) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| SCHEMBL3609605 | 0.93 | DRD2 (0.87) | DRD2DRD3ADRB1HTR1ACYP1A2 | |
| Hydrochloric Acid SCHEMBL253371 | 0.92 | DRD2 (0.84) | DRD2DRD3ADRB1HTR1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 949 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527227-B | Preparation method of kalirazine | 四川弘远药业有限公司 | 2024-06-21 | — | — | CN | claimed |
| CN-116178307-B | Synthesis method of 1- (2, 3-dichlorophenyl) piperazine hydrochloride | 浙江大洋生物科技集团股份有限公司 | 2024-05-14 | — | — | CN | claimed |
| US-20240024310-A1 | CARBOSTYRIL DERIVATIVES AND MOOD STABILIZERS FOR TREATING MOOD DISORDERS | OTSUKA PHARMA CO LTD (JP) | 2024-01-25 | — | — | US | claimed |
| EP-4209474-A1 | METHOD FOR MODIFYING THE SURFACE PROPERTIES OF ARTIFICIAL STONE AND ARTIFICIAL STONE MODIFIED BY THE METHOD | N-Tec GmbH (DE) | 2023-07-12 | — | — | EP | claimed |
| CN-116178307-A | Synthesis method of 1- (2, 3-dichlorophenyl) piperazine hydrochloride | 浙江大洋生物科技集团股份有限公司 | 2023-05-30 | — | — | CN | claimed |
| CN-109476617-B | Industrial process for preparing cariprazine | 吉瑞工厂 | 2023-04-04 | — | — | CN | claimed |
| CN-114751873-A | Preparation method of 1- (2, 3-dichlorophenyl) piperazine | 扬州市普林斯医药科技有限公司 | 2022-07-15 | — | — | CN | claimed |
| CN-114539184-A | Preparation method of cariprazine intermediate | 泰州精英化成医药科技有限公司 | 2022-05-27 | — | — | CN | claimed |
| CN-114539185-A | Preparation method of cariprazine and intermediate thereof | 上海博志研新药物技术有限公司 | 2022-05-27 | — | — | CN | claimed |
| EP-3481811-B1 | INDUSTRIAL PROCESS FOR THE PREPARATION OF CARIPRAZINE | RICHTER GEDEON NYRT (HU) | 2022-05-25 | — | — | EP | claimed |
| US-20070032651-A1 | Process for the preparation of carbostyril derivatives, such as aripiprazole and its intermediates | DELMAR CHEMICALS, INC. (CA) | 2007-02-08 | — | — | US | claimed |
| US-20060258869-A1 | Process for the preparation of aripiprazole | ALEMBIC LIMITED (IN) | 2006-11-16 | — | — | US | claimed |
| CN-1784385-A | Process for the preparation of carbostyril derivatives, such as aripiprazole and its intermediates | DELMAR CHEMICALS INC (CA) | 2006-06-07 | — | — | CN | claimed |
| US-20060079689-A1 | Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones | CHEMAGIS LTD. (IL) | 2006-04-13 | — | — | US | claimed |
| WO-2006030446-A1 | PROCESS FOR THE PREPARATION OF POLYMORPHS, SOLVATES OF ARIPIPRAZOLE USING ARIPIPRAZOLE ACID SALTS | MATRIX LABORATORIES LTD (IN) | 2006-03-23 | — | — | WO | claimed |
| EP-1625116-A1 | PROCESS FOR THE PREPARATION OF CARBOSTYRIL DERIVATIVES,SUCH AS ARIPIPRAZOLE AND ITS INTERMEDIATES | Delmar Chemicals Inc. (CA) | 2006-02-15 | — | — | EP | claimed |
| CN-1235880-C | Quinolinenone kind derivative and its accetable salt, its preparation method, application in preparation of alipyrazole and preparation of alipyrazole | CHONGQING MEDICINE INDUSTRY IN (CN) | 2006-01-11 | — | — | CN | claimed |
| CN-1562973-A | New method for preparing Aripiprazole | NO 2 ARMY MEDICAL COLLEGE P L (CN) | 2005-01-12 | — | — | CN | claimed |
| WO-2004099152-A1 | PROCESS FOR THE PREPARATION OF CARBOSTYRIL DERIVATIVES, SUCH AS ARIPIPRAZOLE AND ITS INTERMEDIATES | DELMAR CHEMICALS INC. (CA) | 2004-11-18 | — | — | WO | claimed |
| CN-1513838-A | Pot cooking sythesis method of alipyracole | 江苏吴中苏药医药开发有限责任公司 | 2004-07-21 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032651-A1 | Process for the preparation of carbostyril derivatives, such as aripiprazole and its intermediates | CYP4F8, CYP2A6, CYP2B6 | DRD2 575/4885DRD3 956/4885ADRB1 1721/4885 |
| US-20060258869-A1 | Process for the preparation of aripiprazole | CYP2F1, CYP3A4, CYP2A7 | DRD2 266/4885DRD3 452/4885ADRB1 199/4885 |
| US-20060079689-A1 | Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones | HRH2, CYP2J2, HTR7 | DRD2 370/4885DRD3 1405/4885ADRB1 122/4885 |
| US-20240024310-A1 | CARBOSTYRIL DERIVATIVES AND MOOD STABILIZERS FOR TREATING MOOD DISORDERS | DRD2, CHRNA6, GABRA6 | DRD2 1/4885DRD3 52/4885ADRB1 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.