Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826863 | 0.85 | ALDH1A1 (0.36) | ALDH1A1MAPTHTTMAPK1GAA | |
| SCHEMBL4057141 | 0.83 | PDE4B (0.41) | ALDH1A1MAPTHTTMAPK1GAA | |
| SCHEMBL1997021 | 0.83 | MAPK1 (0.41) | ALDH1A1MAPTHTTMAPK1GAA | |
| SCHEMBL2828338 | 0.82 | SMN1; SMN2 (0.41) | ALDH1A1MAPTMAPK1GAAKMT2A | |
| SCHEMBL1994594 | 0.82 | ALDH1A1 (0.37) | ALDH1A1MAPTHTTMAPK1GAA | |
| SCHEMBL2828096 | 0.81 | SMN1; SMN2 (0.35) | ALDH1A1MAPTHTTMAPK1KMT2A | |
| SCHEMBL1995589 | 0.81 | MAPK1 (0.41) | ALDH1A1MAPTHTTMAPK1GAA | |
| SCHEMBL5336868 | 0.80 | MAPK1 (0.34) | ALDH1A1MAPTHTTMAPK1GAA | |
| SCHEMBL2828825 | 0.80 | KMT2A (0.40) | ALDH1A1MAPTMAPK1GAAKMT2A | |
| SCHEMBL2824227 | 0.79 | PDE4B (0.34) | ALDH1A1MAPTMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |